Previously I have touched on my summer research project on tendinopathy but today I thought I would share a bit of what I have done with you all, enjoy!
The driving force behind my research was due to the fact that soft tissue disorders represent the third most common musculoskeletal condition in the UK with 18 cases per 1000. These primarily affect tendons, accounting for 30% of all rheumatological consultations with a general practitioner. Causes are multifactorial but with an ever increasing number of professional athletes and also an ageing population whose tendons decrease in elasticity; there is an annual estimated cost to the NHS of £250 million. Though molecular pathophysiology of tendinopathy remains incompletely understood key inflammatory mediators such as proinflammatory cytokines are found to play a vital role.
The extracellular matrix molecule tenascin-C is highly expressed during embryonic development, in pathological situations such as chronic inflammation, cancer. By this report it is found to be at significantly higher levels during diseased tendon tissue repair as compared to healthy tendons to carry out its role as an inflammatory mediator and induce inflammation in attempts to repair the diseased tendon. Tenascin-C prolongs inflammation at site of trauma and leads to further tendon damage. These results provide useful insight into the complex cross-regulation of inflammation and tissue remodelling mediated by tenascin-C.
Some background information
Tendons are a band of flexible fibrous connective tissue which connects muscle to bone. They are present in joints and largely inelastic to conserve energy whilst transmitting the contractile movement of muscle to move bone. Despite the frequent mention of tendinopathy, tendons are in fact extremely tough it is found that collagen fibrillogenesis begins as an assembly of collagen molecules in a series of extracellular compartments, progressing through post-depositional maturation leading to thicker and longer fibrils and ending in their coalescence in the final stages of fibre production.
One of the most important laws of Physics is perhaps one we have all heard once in a while – the second law of thermodynamics.
This law states that the entropy – in a closed system – in which we can infer as the Universe, will always increase.
A common misconception with the term entropy is that it is a measure of disorder. A “disordered” state does not necessarily mean that it has high entropy and vice versa. Entropy is rather the number of ways particles can be arranged. We can take tea and milk as an example, as many people do. Looking at the tea and milk system, at the instantaneous moment when you pour milk into tea, it is perceived to have low entropy, this is because the milk molecules are virtually sitting on top of the tea molecules. When you wait for a second or two until the milk starts to blend and dissolve into the tea, the system begins to increase in entropy, because there are so many more ways for the milk and tea molecules to arrange themselves in this sense, rather than being stacked on top of each other. Continue reading →
From Monday 24th to Friday 28th July 2017 I had attended a residential Sciences Summer School which made me even more set on a future career in STEM (which I didn’t think was possible, haha) and especially medicine. Moreover, I made an abundance of fellow nerd friends who didn’t make me feel as lonely. There were a total of 58 fifth year pupils from all different backgrounds, Scottish, English, Welsh and 1 lone Northern Irish guy but somehow we all connected in a way which prior to the summer school, I believe to be impossible in the span of only a week.
To give myself enough time to travel to the college, I had packed up my bags a day before and arrived to explore the city. Like the tourist I was, I stocked up on a plethora of various fridge magnets depicting medieval buildings and misleadingly sunny postcards which did not accurately depict the British weather. We (10 other people who also travelled down on Sunday) met and were instantly friends. I tried my hand at the out of tune piano and out problems just melted away for a while under the diminishing sunlight.
After everyone else arrived and the different procedural introductions we got stuck in problem solving. (Note: the icebreaker we had to go through did not in fact break-the-ice for it was a bingo involving facts of students. An absurd example being to find someone with blue sockswhich I was only one of a precious few.) The director of studies did not treat us like kids, as a brilliant mathematician he questioned our intuition. After explaining Claude Shannon’s Information theory, he asked an array of mind-bending questions, but even the simplest one caused commotion amongst budding mathematicians:
“I have a bottle and a cap, together costing £1.10. The bottle costs exactly £1 more than the cap so my questions to you is: How much does the cap cost?”
While my lovely co-writer friend Jiangmin has been having a summer holiday filled with medicine, biological research and UKCAT revision (good luck!), she’s headed off this week to complete a Summer school course – just wanted to say, all the best Jiangmin!
I thought this week I might leave Physics aside for a little and talk about the importance of space flight and exploration, especially the Mars issue.
Many leading scientists believe that in order for humans to progress and maintain our survival we must think about progressing in terms of space exploration, whether that be missions like Juno and Cassini to aid research on planetary science, missions like Voyager – the furthest space craft from Earth to explore the outskirts of the solar system or actually sending humans to Mars which seems to either be the general public’s cup of tea, or not.
As mentioned in one of my previous posts [click here] this summer I am undertaking a biomedical research project in collaboration with the Nuffield foundation on the topic of: “The role of Tenascin C in tendinopathy”.My main goal for tackling on this ‘challenge’ (I guess) was to engage in some real life science and to better myself in preparation for university. Though I am fortunate to attend a school which go out of their way to provide specialised scientific equipment, I had never experienced university style labs in (as the researchers I worked with called it) the big bad world. I realised that I took for granted the seemingly simple apparatuses such as autoclaves and centrifuges as some undergraduates haven’t even seen one in real life until university, never mind using them. I was overjoyed to leave the world of school bucket chemistry behind which solely consisted of school technicians tirelessly making up solutions only for us to haphazardly throw them all together to see the really tell-tale signs such as a colour change. No, I savoured every moment of making my own discoveries, never again shall I robotically repeat the same boring experiments to end up with a result I already knew.
Black Holes seem like something that only exists in Science fiction, like Dark Matter and Energy, however, these astronomical objects are in fact at the heart of theoretical research within Cosmology. Research involving Black Holes may likely help us uncover more about the mysteries of Quantum Gravity, something Physicists believe to be the Theory of Everything.
In simple terms, a Black Holes is a region in which the gravitational influence is so strong that nothing, not even light, can escape its pull beyond the Event Horizon, which means that the Escape velocity is essentially greater than the speed of light. Escape velocity is the speed in which an object needs to travel at to escape a gravitational field, e.g. the Earth’s.
Hey, Y’all! last week I attended the week long program, medic insight (which is as self-explanatory as it sounds) hence why I am late in posting and I have decided to share my experience for future aspiring medics. The program intends to allow fifth-year pupils in high school (i.e me) to experience the life of a typical medical student and much more. I have included their “About” page below so they can say for themselves.
The Glasgow one I attended was only in its 3rd year running, a baby when compared to its Edinburgh and Dundee counterparts. The Glasgow program runs twice, I attended week 1 as seen from my name card.
I felt one of the best things were how meticulously planned everything was, from tirelessly scouring through several hundred applications (from Glasgow alone!!!) in order to admit 50 lucky people for each week and giving each of them a personalised timetable. This was an impressive feat, considering it is run by Glasgow medics who have their own lectures and exams outside of organising Medic Insight.
Bonjour fellow bloggers and blog viewers, I just came back from a fantastic residential week at Scottish Space School and I just thought it would be great to share this great experience with you all.
The Scottish Space School, as I mentioned several months before in a “thoughts” post, is a residential week aimed at students in their second last year of high school who are interested in pursuing a career in Engineering, Space Exploration or something along these lines, and is situated in the University of Strathclyde, Glasgow. This year I was one of the lucky 100 students to be selected from over 500 applicants based around Scotland to attend the week running from 11th to 16th June 2017.
The week-long programme included different engineering workshops, lectures from senior NASA guests, talks from people who worked in the Space industry, fun social events and many more.
The term ‘alkaloids’ may be unfamiliar to most of us but if I start naming some examples which fall into this group of ‘nitrogenous bases secondary metabolites’, you will know what I mean. Some of the big names include morphine, quinine, strychnine, nicotine etc. basically a continuous list of –ine’s. The thing to note is that though the alkaloids were attributed to pharmacologically active bases derived from plants however, animals (including us!), insects and microbes also produce them.
After the many ramblings I made regarding Dark Matter previously, I want to turn around and think about Baryonic Matter again. Ordinary Matter is something that physicists know much more about than the mysterious Dark Matter and Dark Energy, even though in reality they do make up more than 95% of our known Universe. We are more knowledgeable about Baryonic Matter because of its presence all around us, after all, it is everything we can see and detect: from forms of life, elements in the Earth’s crust and mantle, buildings, cars, the Earth, the Sun, all of the stars… you get the idea.
Now, the stuff that makes up the matter. Firstly what comes to our mind may be elements, which are a table of 100 odd substances that are often called the “primary constituents of matter”. These elements can be identified through their chemical properties and are placed in the Periodic table in order of increasing atomic number (the number of protons in its atom’s nucleus).
Atoms are another level down from the elements of the periodic table, which distinguishes different types of atoms. Atoms themselves is another study on its own. In the early 20th Century, Rutherford and a couple other physicists discovered an awful lot that directly correlates to our modern understanding of the atom through an experiment – firing alpha particles at a piece of gold leaf.