The De Broglie Hypothesis – Physics Research Project #1

Hello, it’s been a while!

News:  Jiangmin has decided to settle as a freelance writer and will be publishing only on an occasional basis from now on.

If you can still remember me from my long absence, then great! I can happily say that my Advanced Higher exams are done and dusted, and I very recently graduated from high school. This Autumn I’ll be starting an Integrated Masters degree in Theoretical Physics…somewhere, I’ll update you on that one in August.

As you may know, I took Advanced Higher Physics this year and around 30% of the qualification is made up of a research project which must be based on a topic of the course. For the previous qualifications, it was required to do your project on a pre-selected topic, which consequently took away the fun, because the topics selected were either classical mechanics or electricity, I.e. not modern physics. But with this? I thought, QUANTUM IT IS.

One of the most amazing things in the course is the de Broglie hypothesis of Quantum mechanics which I very quickly made my project title.

Some background on the de Broglie Hypothesis

In the 20s, the early stages of the construction of quantum theory, a physicist Louis de Broglie postulated the wave particle duality of nature suggesting that all matter had both wave and particle properties.

Particles and waves are very different things. Particles are localised – they are in one place at one time and therefore can have a precise position. Particles have mass, they can bounce off one another and transfer energy through collision. Waves, on the other hand, are delocalised – to assign a “position” to a wave doesn’t really make much sense, waves can carry energy without the net transfer of mass, capable of interference, diffraction, reflection and so on.

Advances in tendinopathy

Previously I have touched on my summer research project on tendinopathy but today I thought I would share a bit of what I have done with you all, enjoy!

The driving force behind my research was due to the fact that soft tissue disorders represent the third most common musculoskeletal condition in the UK with 18 cases per 1000. These primarily affect tendons, accounting for 30% of all rheumatological consultations with a general practitioner. Causes are multifactorial but with an ever increasing number of professional athletes and also an ageing population whose tendons decrease in elasticity; there is an annual estimated cost to the NHS of £250 million. Though molecular pathophysiology of tendinopathy remains incompletely understood key inflammatory mediators such as proinflammatory cytokines are found to play a vital role.

This little fella is tenascin-C

The extracellular matrix molecule tenascin-C is highly expressed during embryonic development, in pathological situations such as chronic inflammation, cancer. By this report it is found to be at significantly higher levels during diseased tendon tissue repair as compared to healthy tendons to carry out its role as an inflammatory mediator and induce inflammation in attempts to repair the diseased tendon. Tenascin-C prolongs inflammation at site of trauma and leads to further tendon damage. These results provide useful insight into the complex cross-regulation of inflammation and tissue remodelling mediated by tenascin-C.

Some background information

Tendons are a band of flexible fibrous connective tissue which connects muscle to bone. They are present in joints and largely inelastic to conserve energy whilst transmitting the contractile movement of muscle to move bone. Despite the frequent mention of tendinopathy, tendons are in fact extremely tough it is found that collagen fibrillogenesis begins as an assembly of collagen molecules in a series of extracellular compartments, progressing through post-depositional maturation leading to thicker and longer fibrils and ending in their coalescence in the final stages of fibre production.

 

Figure 1Various tendons on the body which are affected by tendinopathy especially the Achilles tendon and rotator cuff

My month as an immunologist

As mentioned in one of my previous posts [click here] this summer I am undertaking a biomedical research project in collaboration with the Nuffield foundation on the topic of: “The role of Tenascin C in tendinopathy”. My main goal for tackling on this ‘challenge’ (I guess) was to engage in some real life science and to better myself in preparation for university. Though I am fortunate to attend a school which go out of their way to provide specialised scientific equipment, I had never experienced university style labs in (as the researchers I worked with called it) the big bad world. I realised that I took for granted the seemingly simple apparatuses such as autoclaves and centrifuges as some undergraduates haven’t even seen one in real life until university, never mind using them. I was overjoyed to leave the world of school bucket chemistry behind which solely consisted of school technicians tirelessly making up solutions only for us to haphazardly throw them all together to see the really tell-tale signs such as a colour change. No, I savoured every moment of making my own discoveries, never again shall I robotically repeat the same boring experiments to end up with a result I already knew.